Journal: Pain

Article Title: Pharmacologic attenuation of cross-modal sensory augmentation within the chronic pain insula

doi: 10.1097/j.pain.0000000000000593

Figure Lengend Snippet: Patients with fibromyalgia report increased affective unpleasantness in response to visual stimulation. (A) A dynamic visual stimulus was presented to individuals with fibromyalgia and healthy controls wherein participants viewed a 3-minute movie clip of alternating 20-second blocks of a flashing (8 Hz) blue-yellow annulus checkerboard (left panel) and a static fixation cross (right panel). The checkerboard was presented in increasing illumination levels, ranging from 4.5 to 78 lux. (B) Participants rated the unpleasantness evoked by the visual stimulus at each illumination level (left panel), and the overall unpleasantness of the entire visual task (right panel). FM = patients with fibromyalgia; HC = healthy control participants. *Significant pairwise comparisons.

Article Snippet: Participants underwent a 3-minute dynamic visual stimulation task developed in MATLAB (Mathworks, Natick, MA) that consisted of alternating 20-second blocks of a flashing (8 Hz frequency) blue-yellow annulus checkerboard and a static fixation cross (Fig. A).

Techniques: Control

Journal: Pain

Article Title: Pharmacologic attenuation of cross-modal sensory augmentation within the chronic pain insula

doi: 10.1097/j.pain.0000000000000593

Figure Lengend Snippet: Age, clinical pain, and responses to experimental sensory stimulation.

Article Snippet: Participants underwent a 3-minute dynamic visual stimulation task developed in MATLAB (Mathworks, Natick, MA) that consisted of alternating 20-second blocks of a flashing (8 Hz frequency) blue-yellow annulus checkerboard and a static fixation cross (Fig. A).

Techniques:

Journal: Pain

Article Title: Pharmacologic attenuation of cross-modal sensory augmentation within the chronic pain insula

doi: 10.1097/j.pain.0000000000000593

Figure Lengend Snippet: Increased brain activation in response to aversive visual stimulation is associated with clinical pain intensity in fibromyalgia. (A) Individuals with fibromyalgia (FM) displayed greater functional magnetic resonance imaging blood–oxygen-level-dependent (BOLD) activations in right anterior insula than healthy controls (HC) during the presentation of a dynamic visual stressor. (B) Within the FM group, anterior insular activation was positively correlated with the degree of clinical pain measured using a 100-mm visual analog scale (VAS). IC, insular cortex.

Article Snippet: Participants underwent a 3-minute dynamic visual stimulation task developed in MATLAB (Mathworks, Natick, MA) that consisted of alternating 20-second blocks of a flashing (8 Hz frequency) blue-yellow annulus checkerboard and a static fixation cross (Fig. A).

Techniques: Activation Assay, Functional Assay, Magnetic Resonance Imaging

Journal: Pain

Article Title: Pharmacologic attenuation of cross-modal sensory augmentation within the chronic pain insula

doi: 10.1097/j.pain.0000000000000593

Figure Lengend Snippet: Specific attenuation of insular response to aversive visual stimulation by pregabalin. (A) A subset of 17 patients with fibromyalgia underwent aversive visual stimulation during functional magnetic resonance imaging (fMRI) both before and after pregabalin and placebo administration. After the pregabalin period, a significant reduction in bilateral insular blood–oxygen-level-dependent (BOLD) activation in response to the visual stimulus was observed (left). No reductions in insular activation were observed after placebo treatment (right). Lines denote fMRI BOLD values for each participant (pre and post drug or placebo). Blue lines represent individuals with a decrease in BOLD activity, whereas red lines denote increases in BOLD activity. (B) A direct contrast between pregabalin and placebo periods shows decreased visual stimulus-evoked BOLD response in the right insula after pregabalin treatment.

Article Snippet: Participants underwent a 3-minute dynamic visual stimulation task developed in MATLAB (Mathworks, Natick, MA) that consisted of alternating 20-second blocks of a flashing (8 Hz frequency) blue-yellow annulus checkerboard and a static fixation cross (Fig. A).

Techniques: Functional Assay, Magnetic Resonance Imaging, Activation Assay, Activity Assay